Editorial Natural Killer Cells in Pulmonary Arterial Hypertension
نویسندگان
چکیده
Pulmonary arterial hypertension (PAH) is a progressive disorder of the pulmonary vasculature characterized by the constriction of precapillary pulmonary arteries, leading to sustained elevated pressure in pulmonary vessels. The chronic strain and then failure of the right heart leads to significant morbidity and mortality in affected patients. In untreated patients the prognosis can be as poor as in patients with malignancies.
منابع مشابه
Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension.
BACKGROUND Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling. Pulmonary arterial hypertension (PAH) is characterized by severe pulmonary vascular remodeling and has long been associated with immune dysfunction. Despite this association, a role for NK cells in disease pathology has not yet been des...
متن کاملNatural killer cells in pulmonary arterial hypertension: a force on the dim or the bright side?
Pulmonary arterial hypertension (PAH) is a progressive disorder of the pulmonary vasculature characterized by the constriction of precapillary pulmonary arteries, leading to sustained elevated pressure in pulmonary vessels. The chronic strain and then failure of the right heart leads to significant morbidity and mortality in affected patients. In untreated patients the prognosis can be as poor ...
متن کاملNatural killer cell-mediated immune deficiency or compromise in patients with portopulmonary hypertension
Portopulmonary hypertension (POPH) is a form of pulmonary arterial hypertension (PAH) in the setting of portal hypertension, and is associated with a poor prognosis [1]. The underling etiological cause of POPH is poorly understood [1]. Previously we have reported T cell-mediated immune deficiency or compromise in patients with chronic thromboembol-ic pulmonary hypertension (CTEPH), idiopathic p...
متن کاملA case of severe pulmonary hypertension associated with common arterial trunk and VSD in a 9 years old child
Background: Common arterial trunk (CAT) is a rare congenital heart disease, and often leads to the early development of pulmonary hypertension and disability. Among the critical structural heart defects, the frequency of CAT is 3%, which reflects the severe hemodynamic disturbances. The natural course of the disease is characterized by a high mortality rate up to 88% during the first year of li...
متن کاملTHE EFFECTS OF CAPTOPRIL ON PULMONARY AND SYS TEMIC ARTERIAL PRESSURES IN HIGHALTITUDE PULMONARY HYPERTENSION
The purpose of this investigation was to assess the effect of captopril on both systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years) with HAPH and mild to moderate systemic arterial hypertension were included in the study. All patients underwent right heart catheterization with measurem...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012